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Tuesday, July 14, 2020 | History

2 edition of role of Epstein-Barr virus in the pathogenesis of nasopharyngeal carcinoma found in the catalog.

role of Epstein-Barr virus in the pathogenesis of nasopharyngeal carcinoma

Christopher William Dawson

role of Epstein-Barr virus in the pathogenesis of nasopharyngeal carcinoma

by Christopher William Dawson

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  • 21 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Birmingham, Department of Cancer Studies.

Statementby Christopher William Dawson.
ID Numbers
Open LibraryOL21202342M

  Pathogenesis of nasopharyngeal carcinoma: histogenesis, EBV infection and tumour microenvironment 4. Epidemiology and population screening 5. Establishment of NPC cell line, patient-derived xenografts (PDXs) and immortalized nasopharyngeal epithelial cells for NPC and EBV infection study 6. The Epstein Barr Virus is among the very first oncogenic viruses to be identified as culprits of human malignancies. Its role as an etiologic agent of breast cancer however remains debated despite mounting molecular evidence. In this chapter we address the challenge of multiple molecular etiologies of breast cancer (BC) with emphasis on the Epstein Barr Virus (EBV) as a Author: Ghimja Fessahaye, Muntaser E. Ibrahim.

  Role of EBV in Cancers EBV is thought to play a critical role in two cancers: Burkitt's lymphoma and nasopharyngeal CDC sites EBV as a factor in these cancers, but the WHO lists EBV as one of 3 viruses known to be the causative agents in cancer. Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA Nephropathy Katerina Zachova 1, Petr Kosztyu 1, Josef Zadrazil 2, Karel Matousovic 3, Karel Vondrak 4, Petr Hubacek 5, Bruce A. Julian 6, Zina Moldoveanu 7, Zdenek Novak 8, Klara Kostovcikova 9, Milan Raska 1,7 * and Jiri Mestecky 6,7,9 *.

While the contribution of Epstein-Barr virus (EBV) to the development of B cell tumours is well-studied, its precise role in the pathogenesis of epithelial cancers, such as nasopharyngeal carcinoma (NPC) and EBV-associated gastric cancer (EBVaGC), remains largely : Sally Roberts, Ieisha Pentland, Paul McCormack, Joanna L. Parish. The Epstein-Barr virus (EBV), isolated in , continues to draw worldwide attention as an important human pathogen. Its impor­ tance is largely related to the continuing accumulation of evidence that implicates EBV as an etiological factor for .


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Role of Epstein-Barr virus in the pathogenesis of nasopharyngeal carcinoma by Christopher William Dawson Download PDF EPUB FB2

Endemic nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus (EBV) type II latent infection, and tumor cells expressing such viral antigens are attractive targets for treatment. As tumor cell survival is dependent on their ability to evade T-cell immunity, immunotherapy in NPC traditionally focuses on restoration of T-cell.

Epstein–Barr Virus Infection, BART-microRNAs, and Nasopharyngeal Carcinoma Pathogenesis The Contribution of Tumor Microenvironment to Nasopharyngeal Carcinoma Pathogenesis The Dynamic Interaction of Tumor Microenvironment Cells With Epstein–Barr Virus-Infected Nasopharyngeal Carcinoma Cells 53Author: C.M.

Tsang, C.M. Tsang, K.W. Lo, John M. Nicholls, S.C.M. Huang, S.W. Tsao. The detection of the Epstein-Barr virus (EBV) nuclear antigen and viral DNA in nasopharyngeal carcinoma has revealed that EBV can infect epithelial cells and is associated with their malignant transformation.

[] Copies of the EBV genome have been found in cells of preinvasive lesions, suggesting that it is directly related to the process of transformation. Epstein-Barr virus (EBV) is convincingly associated with gastric cancer, nasopharyngeal carcinoma, and certain lymphomas, but its role in other cancer types remains : Nancy Raab-Traub.

Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA Nephropathy. (nasopharyngeal carcinoma, Ig-producing cells in the nasopharyngeal and upper respiratory. Abstract. Pathogenesis of nasopharyngeal carcinoma (NPC) has not yet been fully understood, however, as a result of various studies conducted during last!0-!5 years it has become possible to have a better understanding of the process whereby a normal cell in Cited by: 1.

A new diagnostic marker for secreted Epstein-Barr role of Epstein-Barr virus in the pathogenesis of nasopharyngeal carcinoma book encoded LMP1 and BARF 1 oncoproteins in the serum and saliva of patients with nasopharyngeal carcinoma.

Clin Cancer Res ; 13(17)–Cited by: 7. A very educational read. So if you have a family member that deals with the rare Chronic Active Epstein-Barr Virus, or even just the lesser evil - Reactivated Epstein-Barr Virus, you know how negatively it can affect someone's quality of life. They can develop all kinds of auto-immune disorders, and organ by: 1.

Nasopharyngeal Carcinoma: From Etiology to Clinical Practice discusses NPC from basic science, to clinical management through the perspective of members of the Centre for Nasopharyngeal Carcinoma Research in Hong encompasses not only the most detailed information about multiple aspects of NPC, but also the modern day research model of.

Nasopharyngeal carcinoma (NPC), previously known as lymphoepithelioma, is a malignancy arising from the epithelium of the nasopharynx. Endemic to China, the malignancy shows a variable rate of occurrence ranging from high incidence in the Southern part of China to a low rate in the White population and Northern China with the incidence ranging from 15 to 50 per Epstein-Barr virus (EBV) is a human DNA tumor virus with an extraordinarily diverse oncogenic potential.

No other virus, human or otherwise, has shown the ability to contribute to malignant transformation in such a variety of cell backgrounds.

Studies of EBV related malignancies in immunodeficiency states (posttransplant and AIDS) have provided insight into the significance Cited by: The properties of the Epstein–Barr virus. The EBV is a ubiquitous microorganism present in practically every adult human being.

It is a DNA virus belonging to the family of Herpesviridae and the subfamily of gamma herpesviruses – it is also referred to as the human herpesvirus type 4 (HHV-4). The structure of EBV is similar to that of other herpesviruses: the linear, double Cited by: 8.

N. Raab-Traub, Nasopharyngeal Carcinoma: An Evolving Role for the Epstein-Barr Virus, Curr Top Microbiol Immunol (), – [15] D.

Wang, D. Liebowitz and E. Kieff, An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells, Cell 43 (), –Author: Lirong Wu, Jingyi Wang, Danxia Zhu, Shiyu Zhang, Xin Zhou, Wei Zhu, Jun Zhu, Xia He.

'This book covers all the necessary aspects of our knowledge on nasopharyngeal carcinoma, from anatomy, histopathology, epidemiology, experimental studies, clinical manifestations, clinical and laboratory diagnostic methods to the latest imaging techniques.

It also contains all of the information necessary for the clinician to reach the proper staging of nasopharyngeal. Nasopharyngeal carcinoma is strongly associated with Epstein-Barr virus (EBV) infection.

In addition to the serological evidence of infection in more than 98% of patients, EBV DNA is present as a monoclonal episome in the nasopharyngeal carcinoma cells, and tumor cells can have EBV antigens on their cell surface.[] The circulating levels of EBV DNA and serologic.

Infectious mononucleosis was first described by Sprunt and Evans in the Bulletin of the Johns Hopkins Hospital in They described the clinical characteristics of Epstein-Barr virus (EBV) infectious mononucleosis. Risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which Epstein-Barr virus (EBV) infection is the mostly investigated.

The study into mechanism of EBV in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. The Epstein‐Barr virus (EBV) has been studied for over 25 years as a probable cause of certain human cancers, including nasopharyngeal carcinoma (NPC).

This is a low‐incidence head and neck cancer in Western countries (including the USA), but is the third‐leading cancer in males in Southeast Asia.

Evidence supporting an etiologic relation between this virus and NPC includes. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole­ cular virology, since it is the cause of infectious mononu­ cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma.

I Epstein-Barr Virus: Clinical and Laboratory Characteristics of Infectious Mononucleosis / Hugo Juarez Olguin --ch. II The Role of Epstein-Barr Virus in the Management of Undifferentiated Nasopharyngeal Carcinoma / Wei Gao --ch.

III Epstein-Barr Virus (EBV) -Associated B-Cell Lymphoma / David M. Aboulafia --ch. IV The Role of the Epstein-Barr. The first section describes the oncogenic potential of the Epstein-Barr Virus along with a thorough appraisal of its role in nasopharyngeal carcinoma and B-cell lymphoma.

This part is essential for situating EBV in the field of oncogenesis, and presenting the pivotal role of EBV in contemporary oncology and transplantology.Antibodies to Epstein-Barr virus in patients with nasopharyngeal carcinoma and in comparison groups. Ann Otol Rhinol Laryngol. ; Medline, Google Scholar: Chan KC, Hung EC, Woo JK, et al.

Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program. Cancer. ; Cited by: The Epstein-Barr virus (EBV) reactivation corresponds to the activation of EBV global replication involving not only the origin of the latent viral replication but also that of the origin of lytic replication.

During this reactivation, a minority of B cells infected with EBV in its latent form enter the lytic phase. During this phase, all EBV proteins are produced, enabling the assembly of Author: Emmanuel Drouet.